Fentanyl, sufentanil, alfentanil and myocardial function

Fentanyl, sufentanil, alfentanil and myocardial function.

REFERENCE 1 Miller DR, WellwoodM, Teasdale SJ et al. Effects of anaesthetic induction on myocardial function and metabolism: a comparison of fentanyl, sufentanil and alfentanil. Can J Anaes 1988; 35: 219-33. on-line pressure-volume loop eapability to pin-point more precisely ventricular cad systole for future studies. Finally, although the negative effects on cardiac function were observed, to ...

The pharmacokinetics of fentanyl, sufentanil and alfentanil: a comparative review.

Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil.

BACKGROUND Despite widespread use, little is known about the comparative pharmacokinetics of intrathecally administered opioids. The present study was designed to characterize the rate and extent of opioid distribution within cerebrospinal fluid, spinal cord, epidural space, and systemic circulation after intrathecal injection. METHODS Equal doses of morphine and alfentanil, fentanyl, or sufe...

Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein.

BACKGROUND The efflux transporter P-glycoprotein, a member of the adenosine triphosphate-binding cassette superfamily, is a major determinant of the pharmacokinetics and pharmacodynamics of the opioid loperamide, a well-recognized antidiarrheal agent. Animal studies indicate that P-glycoprotein limits morphine entry into the brain. In this study, the authors examined whether other opioids of im...

Alfentanil causes less postoperative nausea and vomiting than equipotent doses of fentanyl or sufentanil in outpatients.

BACKGROUND The relative potencies of alfentanil, fentanyl, and sufentanil as a risk factor for postoperative nausea and vomiting have not been determined. They were compared in a randomized study designed to obtain equipotent plasma concentrations of these three opioids at the beginning of the recovery period. METHODS The study included 274 patients treated on an outpatient basis. The steady ...